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KMID : 1137820090300040347
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의공학회지
2009 Volume.30 No. 4 p.347 ~ p.354
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Analysis of Neuronal Activities of Retinal Ganglion Cells of Degenerated Retina Evoked by Electrical Pulse Stimulation
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Ryu Sang-Baek
Lee Jong-Seung
Ye Jang-Hee
Goo Yong-Sook
Kim Chi-Hyun
Kim Kyung-Hwan
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Abstract
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For the reliable transmission of meaningful visual information using prosthetic electrical stimulation, it is required to develop an effective stimulation strategy for the generation of electrical pulse trains based on input visual information. The characteristics of neuronal activities of retinal ganglion cells (RGCs) evoked by electrical stimulation should be understood for this purpose. In this study, for the development of an optimal stimulation strategy for visual prosthesis, we analyzed the neuronal responses of RGCs in rd1 mouse, photoreceptor-degenerated retina of animal model of retinal diseases (retinitis pigmentosa). Based on the in-vitro model of epiretinal prosthesis which consists of planar multielectrode array (MEA) and retinal patch, we recorded and analyzed multiunit RGC activities evoked by amplitude-modulated electrical pulse trains. Two modes of responses were observed. Short-latency responses occurring at 3 ms after the stimulation were estimated to be from direct stimulation of RGCs. Long-latency responses were also observed mainly at 2 - 100 ms after stimulation and showed rhythmic firing with same frequency as the oscillatory background field potential. The long-latency responses could be modulated by pulse amplitude and duration. From the results, we expect that optimal stimulation conditions such as pulse amplitude and pulse duration can be determined for the successful transmission of visual information by electrical stimulation.
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KEYWORD
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Retinal prosthesis, Photoreceptor degeneration, Retinal ganglion cell, Electrical Stimulation, Neural spike train, Field potential
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